AB0240 CORRELATION BETWEEN KLOTHO LEVELS AND ANKLE-BRACHIAL INDEX IN FEMALE RHEUMATOID ARTHRITIS PATIENTS

Background Rheumatoid arthritis (RA) that is a chronic systemic and disabling disease affecting 0.5–1% of the general population, have been strongly linked to accelerated aterosclerosis increased incidence cardiovascular events mortality. Klotho membrane-bound or soluble antiaging protein, whose protective activity essential for proper function many organs. The association between serum classic risk factors, as well clinical history disease, was also shown. There are lot evidences deficiency correlates with occurrence development coronary artery atherosclerosis, myocardial infarction, left ventricular hypertrophy. Objectives aim this study examine possible levels ankle-brachial index in women RA. Methods This cross-sectional performed Vega-Baja Hospital (Orihuela-Spain) from November 2016 May 2018. We prospectively enrolled 63 consecutive female patients affected by RA followed at (Orihuela-Spain). All included had normal creatinine (Cr) met 2010 American College Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria Ankle-brachial were evaluated using BIDOP model ES-100V3 vascular screening system (Hadeco, Inc, Kawasaki, Japan). Serum (Elabscience, USA) analysed ELISA. Results Our patients, mean (SD) age 53 ± 8 years. majority Caucasian (90.5%). duration 8.5 5.8 Mean 28-joint scores (DAS28) based on erythrocyte sedimentation rate (ESR) indicated low 3.0 1.3. health assessment questionnaire (HAQ) 0.75 0.67. 4.68 1.14 ng/mL. value 0.1. Lower significantly associated lower (r 0.27, p<0.05). Conclusion Decreased peripheral arterial References [1]Kozera L, Andrews J, Morgan AW. Cardiovascular rheumatoid arthritis—the next step: differentiating true biomarkers surrogate measures inflammation. Rheumatology. 2011; 50:1944-1954. [2]Hu MC, Shi M, Cho HJ, Adams-Huet B, Paek Hill K, et al. phosphate modulators pathologic uremic cardiac remodeling. J Am Soc Nephrol. 2015; 26(6):1290–1302. [3]Olejnik A, Franczak Krzywonos-Zawadzka KaBuhna-Oleksy Bil-Lula I. Biological Role Protein Development Diseases. Biomed Res Int. 2018; 2018:5171945. Disclosure Interests None declared